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Confessions Of A Methylcobalamin Junkie at Trader’s Narrative

Confessions Of A Methylcobalamin Junkie

methycobalamin altWell, I think it is time I came clean.

I have been taking methylcobalamin. You could say I’m a meth(ylcobalamin) junkie.

Before you start organizing an intervention, I should explain that it is just good old vitamin B12.

It’s just that instead of taking it orally, I’ve been injecting it.

There are many forumulations of vitamin B12:
Cyanocobalamin, Cobalamin, Methylcobalamin, Adenosylcobalamin, Hydroxocobalamin, and Hydroxycyanocobalamin.

I prefer methylcobalamin because your body doesn’t need to convert it to anything, it just absorbs it.

Why not take it orally like other “normal” people? Because when you ingest supplements the absorption rate effects how much benefit you get. Just because you’re taking 100 mg of B12 doesn’t mean your body is actually receiving 100 mg. In fact, chances are you might as well be popping tic tacs for all the B12 you’re giving your body.

Injecting the compound gives your body the best ability to absorb and use it. But shhhh… this is a big secret. The multi-billion dollar supplement and vitamin industry prefers you didn’t think about it.

Your body needs B12 for healthy cell growth and function. Methylcobalamin improves your brain function, memory, nervous system, etc. It also gives you a boost of energy and alertness. If you’re a vegan or vegetarian, then you need B12 more than us omnivores.

So that’s why I load up a syringe and go Chigurh on my lastus vateralis (or intermedius if my aim is off). I’ve spared you a picture of my hairy legs so use your imagination.

Can you take too much? No. Unlike other supplements which you can overdose on, your body doesn’t store excess vitamin B12. But you don’t want to waste it. I usually go with ~1cc every week or so.

I’m not a doctor so don’t be silly and mistake what I write as health advice.
You should always consult a competent professional.

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79 Responses to “Confessions Of A Methylcobalamin Junkie”  

  1. 1 Anonymous

    Jesus Christ!

    Stabbing yourself with a needle is pretty fucking serious way of getting some goddamn vitamins. Did it ever occur to you that this *may not* be the best way of getting vitamins into your system? That your body is throwing away part of the pill because of a good reason? That by directly injecting it into your body your denying some very important metabolic processes, and in effect short circuiting 4 million years of metabolic evolution? Have you heard about the vascular diseases that this causes? the army did this with vitamin c a while back,and nothing good came of it - vascular disease for our troops!

    Fuck the multi-billion dollar supplement and vitamin industry, just eat a goddamn banana! Are they so bad? too much chewing? how about a banana smoothie?

    Mushrooms? Yeast (Vegemite)? Seaweed (Sushi, Miso)?? There ARE better ways then chemical dependencies.

    If you think that you need some injected source of nutrition, the multi-billion dollar supplement has just won your money.

    >”I prefer methylcobalamin because your body doesn’t need to convert it to anything, it just absorbs it.”

    Did you realize that your body just absorbs lead, mercury and other toxins as well?
    Just because it gets absobed quickly doesn’t make it a good thing!

    Your body’s metabolic processes are *the most* mysterious and incomprehensible set of chemical reactions yet to be thoroughly understood by mankind.

    >”I’m not a doctor so don’t be silly and mistake what I write as health advice.
    You should always consult a competent professional.”

    This is great advice, you should follow it yourself! Seriously!

  2. 2 Kristy

    Why do you do this? Do you have a health issue? “Anonymous” brought up some great ideas.

    I enjoy reading your blog. Thanks for all the insight.

  3. 3 Robert

    I am going to disagree with these two. I have been a long time user of B-12 and I agree that it is of much value.

    99% of all people do not understand the value of B-12, how it works and the fact that it is very difficult for your body to absorb (from supplements as opposed to food). Injectable B-12 is really the only alternative for effective B-12 supplementation.

    My only concern with taking B-12 is that there is some limited evidence to that suggests there is a higher risk of developing a brain tumor when using injectable B12 supplementation. The current reasoning as to why this may happen has to do with the manner in which B-12 works in the brain. B-12 supplementation can help protect the existing structures in the brain as well as assist the brain in repairing certain structures.

    These effects can also be used by harmful cancerous cells, thus allowing a brain tumor to form or accelerate in growth through the use of B-12 concentrations that would not otherwise exist in the body.

    Still, though, there is conclusive link, just anecdotal evidence. I believe that the potential benefits outweigh the risks. Still, there are risks. Just very low probablility.

  4. 4 AVI COHEN

    i’ve been taking B-12 b/c it works as a great “hang-over” pill…. pop a few of those puppies before you go to sleep after a hard night and you feel fresh the next morning

    funny post though… keep up the good work…


  5. 5 Babak

    Anon, thanks for your concern, just so it is crystal clear, what I’m doing is ok’ed by my Dr. And to answer your questions, delivering drugs through injection is a safe method. Obviously I’m injecting something that is good for my body not “lead” as you suggest! lol What makes it a good thing is not only that it is absorbed well, but that the compound itself is good. Get it? Talk to your doctor and s/he will set you straight.

    Kristy, I guess some people have a reaction to needles. All of Anon’s ideas are rubbish. He brings up vascular disease but not only does B12 not cause it, in fact doctors use B12 to treat vascular disease !! LoL Anon couldn’t be more wrong if he tried.

    Robert, as I said, consult your doctor. I’ve done that and think this is good for me. Also the formulation may have something to do with it. If you take just regular B12 your body metabolizes it into methylcobalamin. So why not take the direct route?

    Methylcobalamin is the neurologically active form of vitamin B12. The liver does not convert cyanocobalamin, the commonly available form of vitamin B12, into adequate amounts of methylcobalamin, which the body uses to treat or correct neurological defects. Animal studies have shown that high doses of methylcobalamin are effective in neuron regeneration and that there is no known toxicity at these doses.

    Avi, LoL never thought of using it as a hangover cure but thanks for the tip.

  6. 6 Lucy

    I take it sublingually, I feel better than I have in years.

  7. 7 christine limbach

    Where do you get your methylcobalamin?????

    I just started a weekly dose of cyanocobalimin and have seen very little results. PLEASE let me know where you are able to get it. Thank you.

  8. 8 Babak

    christine, maybe you don’t have a deficiency at all - did you consult with your doctor?

  9. 9 Tammie

    I’ve been getting B12 injections for over 6 months and they have relieved horrible PMS along with menstrual migraines that I’d been getting for about 10 years. I’ve been getting the shots at my local health food store but would love to be able to give myself shots at home to save time/money. I was able to get a prescription from my doctor, however, the prescription I got filled was for cyanocobalamin instead of methylcobalamin. Unfortunately I’ve been breaking out with the cyanocobalamin. I must be allergic to the different form of B12 or another ingredient in it that may be different. It seems methylcobalamin may be more expensive and harder to find. I was wondering if you could tell me what pharmacy you get your injectable methylcobalamin? Is it a compounding pharmacy? I’m going to try to get my doctor to give me another prescription if I can find a pharmacy that has methylcobalamin.

  10. 10 Bob

    I just read these posts and I’d like to chime in. I’m hypoglycemic and have been using injectable B12 also. In my case, it helps with fatigue and brain fogging caused by hypoglycemia. I’m not an advocate of injecting anything that comes along but my experience has definetitly been positive w/ B12

  11. 11 sheela

    this information is very bad

  12. 12 Paul


    You base your statement on what? This information is not bad. You are ill-/misinformed. Do some research.

  13. 13 Jeff

    To Tammy - the “cyano” is cyanide. Although its in a form which doesn’t bother most people, apparently some people are especially cyanide sensitive. It sounds like you may be one. Stop taking it!

    Generally, I don’t think theres any real need to inject cobalamin unless you are seriously deficient - just taking large dose methylcobalamin tablets will get you more than enough. Personally I wouldn’t consider injecting myself with anything, let alone something which can easily be taken sublingually. “Anonymous” is right about one thing - the body has evolved to take in B12 orally, so it should be able to do it provided you ingest enough.

  14. 14 Michelle

    Hi - I have some medical problems that require my needing the b12 injections. It is way to expensive to keep going into my doctor to do it, and would prefer to do this at home. All I can find on the internet is the other forms of b12 though. Pleeeeaaase tell me where I can get this form that you are using. I’m desperate! Thanx

  15. 15 Julie

    With a prescription from your Dr., Methylcobalamin injections can be obtained from Hopewell Pharmacy in New Jersey, Coastal Compounding and Post Haste pharmacy amongst others. These are all compounding pharmacies and you should be able to locate them by using google. Hopewell will file insurance for you (depending on your carrier), Coastal and Post Haste will not.

  16. 16 Xan

    Some of these posts show a serious lack of information, which is good to have before forming opinions.

    Although the body is, of course, designed to absorb nutrients, there may be a number of reasons why that doesn’t always work properly. Vitamin B12 in particular has a very complicated assimilation process which can break down in various ways. When this happens B12 deficiency can cause many problems with digestion, poor immunity, brain and nervous disorders, sleep problems, mental fuzziness, low energy, premature aging, muscle weakness, and so on. Taking regular injections has been medically found to be the most effective treatment, and it is a great relief and blessing for many people to have such a simple solution for their serious problems.

    Obviously, if you can’t absorb enough B12 from food through your digestive system taking an oral supplement won’t work either.

    Because I have pernicious anemia I give myself subcutaneous injections, which is not as weird or difficult as one might think once you get used to it. A nurse showed me how, and the fine insulin needles I use hardly hurt at all.

    Recently I’ve been learning that methylcobalamin is used by the body and stored in the liver more effectively than cyanocobalamin, which is what most doctors prescribe. There is some evidence that taking a methylcobalamin sublingually (under the tongue) may be as effective as cyanocobalamin injections, so I’m going to try it.


  17. 17 Michael

    I’ve enjoyed most of your postings. I’ve never posted anything myself. After 6 months of health problems that started with a blocked intestine, I have been diagnosed as B12 deficient. I got my first cyanocobalamin shot about 3 weeks ago and feel somewhat better. However, I’m on an antibiotic regimine for gastritis which may make my B12 deficiency worse. I’ve been on the treatment for a week and have been taking an oral B12 (cyanocobalamin) supplement every other day to (hopefully) keep my B12 levels from dropping. I have a question. Can I switch to methylcobalamin supplements or alternate supplements from day to day? One symptom I continue to experience is irritated/burning tongue. I understand that methylcobalamin is readily useable by one’s body. I have also been eating significant amounts of B12 rich foods. One caution for everyone. If your serum B12 is in the low 200’s, even though that is technically “normal” you may still be deficient. In some countries below 500 is believed to be deficient.

  18. 18 Xan

    Michael, I can tell you from my own experience that sublingual methylcobalamin works much better for me than sublingual cynanocobalamin. My energy stays more level, and I can even take it to handle moments of stress better.

    I am also continuing with the injections, which I seem to need more often than the once-a-month that doctors routinely prescribe. Since I do them myself it’s no problem.

    You have to remember, the reason some of us must take injections or sublinguals is because we can’t assimilate B12 from food or oral supplements.

  19. 19 Yelena

    I had a problem for more than ten years - buzzing and tingling in my feet. Not like the “pins and needles” of a limb going to sleep, but a very pronounced buzzing like my feet were on an electric massager turned on high. I probably spent $20,000 or more looking for answers to this problem that was absolutely destroying my life. At times, it felt so bad, I felt almost suicidal. I was told it was scar tissue - it was not. I was told it was a trapped nerve - it was not. I was told I had nerve damage - I did not. I was told I had MS - I did not. I was told I had diabetes - I did not. Finally, the doctors put it all down to “stress” and told me to stop looking for a solution. Of course I didn’t.

    Finally, someone thought to check my B12 levels. They were only in the mid-100s. Very low. And no wonder. I’m a vegetarian and I didn’t take supplements. To make matters worse, I had been taking Prilosec for about seven years and B12 can’t be absorbed from food when there’s no acid in the stomach.

    I immediately started on sublingual methylcobalamin twice a day. The sublingual tablets work as well as injections and they’re more convenient. Within a week, I was feeling significantly better and within a month, I felt “cured.” However, I do know I’ll have to take sublingual methylcobalamin for the rest of my life or again face the distressing symptoms I lived with for ten and one-half miserable years. I don’t care. Letting a pill dissolve under my tongue twice a day is such a small thing to do for my health. I’m just lucky I don’t have nerve damage because it can occur if the B12 deficiency is severe and goes on long enough. And you don’t have to be very deficient to get symptoms.

    Supplements of cyanocobalamin are okay if you’re not deficient, but if you are, then you need either injections or sublingual methylcobalamin.

    I never thought I’d find a way out of the nightmare I was living in, and if I did, I never thought it would be as easy as letting a tablet dissolve under my tongue twice each day. I can’t emphasize the extreme important of methylcobalamin. In my opinion, everyone should be using it.

  20. 20 Michael

    Hi Yelena, I’m glad you finally figured it out. I had a similar experience but was able to diagnose the problem within 6 months. Like you, I was told that my health problems were due to stress. I’m sure stress is a factor but reducing stress won’t solve the problem. After many tests and ruling out a variety of conditions, I asked the doctor to check my B12. In fact my B12 had already been checked but they didn’t interpret the data. My B12 at 211 was in the “normal” range but clearly it wasn’t normal for me. I had many symptoms including enlarged red blood cells (which the doctor would have known if he had really looked at my lab work), tingling hands and feet, burning tongue, the list goes on and on. Thank God I’m being treated now even though all the symptoms have not comletely gone away. Hopefully over time I’ll get back to normal. It took me many hours of research to isolate B12 deficiency as the culprit. Doctors don’t have that kind of time to spend on each patient. I read somewhere that the average dr only listens to a patient for 16 seconds before starting a diagnosis. Doctors need to be made aware of the symptoms and debilitating effects of B12 deficiency.

  21. 21 bonnie

    I care not for anonymous’ language. Grow up. Proper language comes across better. Not language of a filthy sailer. Wether you’re right or wrong.

  22. 22 Tony B

    I started my cyan 5 weeks ago and am so amazed at how I feel now. I was so far down I was doing 1cc every 3 days….I know that might sound harsh but I have Crohns disease and can not hardly absorb anything. That last shot from the bottle finally got me up and out of bed. FINALLY!!! Now I just do about .7cc every 5 days…or whenever my energy really falls off…1cc seems to really buzz my head so I’ve backed down on the dose..

    I took this upon my self to try after reading on a body building forum and days of investigating this…trying to find some way to get energy and do it safely.

    I’ve been working out for 20 years just so I can keep my body going and staying alive.Exercise is about the best thing you can do for crohns and have a good diet but….. There’s not much I can drink besides tea and water….I’ve spent so much on all the protein drinks and whatever else they come out with only to not be able to get help from them. I even eat 3 lbs of meat a week and still can’t get any nutrition from that.

    I’ve always studied nutrition for the last 20 years and taken care of myself. But this has been a rough year, seriously felt myself going down hill a lil too far…and hadn’t worked out for 6 months…
    So I did the B 12 shot and it sure has made a world of difference to me and now back in the gym. Just wished I would’ve started this 10 years ago….

    Like you said Michael we need to tell the world but then the FDA would pull all this off the market along with the other good stuff our bodies need….just like they did to Ener-B Gel in the 90’s….wow now that was some good B 12 up the nose….that was even 5 times stronger than the shots we take…

    Thinking about trying the super-complex after this next bottle….

    it feels good to be normal again I tell ya that!!!

  23. 23 Dr. Juan C. medina

    Hi , I am a doctor in Natural Medicine graduate in USA , I am using B12 ( Methylcobalamin and Hydrocobalamin)in my patients for different diseases and symtoms ( muscular , nerves , weakness, fatigue , carpal tunnel pain , old people, anemia, very complicate diseases and more). i acn talk all day about vitamins , the results are increable positive and compare with the oral supplement is like compare the mosquito with a elefant , the injection is realy hard thing (very supperior and very effective) , The only problems is that can be toxic ,for this reazon is better consult with a proffesional to see whwt is your problems , doses to use , frecuency to use , Higine , etc.
    About the Doctors said tha the oral use is the same is not true , they say that because is a lot of money in that Industry . If you realy are sick or have very bad symtoms and the solution is B12 you have to use in injection .
    NOTE: Becare with the Cyanocobalamin can be Damage the Eyes
    Thank you to every body

  24. 24 Gordon Persson

    Dr. Medina,

    I appreciate you comments but you might want to consider getting some help with your writing. It would go a long way in having readers take your comments seriously.

  25. 25 Dr. Juan C. Medina

    Hi, Sorry for my bad english and for my comments
    My name is Dr. Juan C. medina . I am in the Medical field for 25 years , I
    have two University Titles ( Biomedical Engineer and Dr. in Oriental
    Medicine ) . Sorry for my writing but my first language is Spanish ( my
    English is terrible) . I can’t resist when I see some body that need be
    helping , for this reason I was participating .I was looking in the internet
    other item and for causality I found you and I didn’t have time to correct
    my writing , sorry again , If I can give my help again writing in you web
    let me know , thank you for your advice
    Juan C. Medina

  26. 26 Bill

    I have read that long term supplementation with the cyanide form of B-12 has resulted in blindness in England but was unable to independently confirm this. But why would you ingest or inject cyanide in your body unless you have cancer and then you would use apricot seeds crossed with insulin. Some web reference attached of interest.

    Sources of Vitamin B12

    As little as 0.3 to 0.65 micrograms per day of vitamin B12 has cured people of megaloblastic anemia;9 however, to add an extra margin of safety I have recommended a higher dosage of 5 micrograms per day. You may be surprised to discover that you cannot purchase these tiny dosages. Supplements sold contain 500 to 5000 micrograms per pill. These exaggerated concentrations will correct by passive absorption B12 deficiency caused by disease of the intestine.16-17 Everyone else is being overdosed by a factor of 1000. If you are an otherwise healthy vegan and are using typical dosages of B12 (500 micrograms or more per pill), a weekly dose of this vitamin will be more than sufficient.

    You will often find B12 sold under its proper name. Because vitamin B12 contains one molecule of the mineral cobalt, the scientific name is Cobalamin. As a food additive and a supplement pill, vitamin B12 is usually found in the form cyanocobalamin. The effectiveness of this “cyanide complex” for treating neurologic problems has been questioned; therefore, other forms, such as methylcobalamin and hydroxycobalamin may be better choices for the prevention and treatment of B12-related conditions.18

    Choosing a bioactive form of B12 is important. There are many B12-like substances called analogues found in food supplements, such as spirulina and other algae—these are ineffective and should not be relied upon.19 Foods fermented by bacteria, such as tempeh, and miso; as well as sea vegetables (nori), have been recommended as sources of B12. Miso and tempeh do not contain B12.20 Nori—the dried green and purple lavers commonly used to make sushi—has been tested and found to have substantial amounts of active vitamin B12 and has been recommended a “most excellent source of vitamin B12 among edible seaweeds, especially for strict vegetarians.”20,21 (Nori obtains its B12 from symbiotic bacteria that live on it.22) However, there is still some uncertainty about nori as a reliable B12 source; therefore, I suggest if you do choose this seaweed that you should monitor your B12 levels by blood tests now, and if adequate, every 3 years.

    In order to minimize your risk of any health problems, I recommend you and your family follow a diet based on starches, vegetables, and fruits. To avoid the extremely rare chance of becoming a national headline, add a reliable B12 supplement. By making this addition to a healthy diet you can’t go wrong, nor will you suffer from any justifiable criticism of your McDougall Diet delivered by well-meaning family and friends.

    Hydroxocobalamin is a unique form of B-12 that participates in detoxification, especially cyanide detoxification. Cyanide levels are often elevated in smokers, people who eat cyanide-containing food (like cassava) and those with certain metabolic defects.

    Excess cyanide in the tissues blocks conversion of cyanocobalamin to methylcobalamin or adenosylcobalamin. In such instances, hydroxocobalamin may be the vitamin B-12 of choice. Hydroxycobalamin is FDA-approved as a treatment for cyanide poisoning.

    Oral Vs. Injectable: Which Delivery System is Preferred?

    Although many people including some physicians still believe that injectable vitamin B-12 is the preferred route of administration, it is well-known and widely accepted that oral vitamin B-12 is equally as effective as injection in treating pernicious anemia and other B-12 deficient states.

  27. 27 ken

    Methyl b12 needs to be injected subq not im. Also, a b12 test is useless. You have to understand the methylation cycle to realize that serumb12 is of no value. Why do kids with autism show very high levels of serum b12? Becasue their methylation is blocked, hence one reason why methylb12 is a major treatment for autism.

  28. 28 Mairead

    I just want to thank everyone for their helpful comments, esp. Dr Juan, and the person who gave the pharmacy names that sell B12 ampoules. I have pernicious anaemia and have been given cyanocobalamin B12 injections every month for the last few years. Towards the end of the month I get bad headaches etc which seem to be getting worse as time goes on. It’s really difficult to get information on which type of B12 injection is best as the only one available according to my Dr here in Ireland that is on prescription is cyanocobalamin. Even the pernicious anaemia society website does not contain much information on different B12 injection types.

    I am going to order hydroxocobalamin and methylcobalamin ampoules and see whether they cause improvement.

    Thanks again.

  29. 29 Tony B.

    Mairead…..Please keep us informed as to which works best for you. The cyanco seems to have lessened its affect on me now.
    I did find a pharmacy that sells the hydroxo for $40.00 for a 100ml bottle….I would like to find the methyl type since I take shots twice weekly…. I did find a B complex 250ml bottle for $6.00 at a pet store but it has the cyanco in it……

    I have crohns disease and get no iron or hardly any food value at all anymore….

    Thanks keep in touch…
    Tony B.

  30. 30 Xan

    Mairead. Just because the usual medical protocol recommends injections once a month, that doesn’t mean you have to wait that long, especially if you do your own injections.

    Each of us needs to work out a program that works best for us. For me that turns out to be a monthly injection of cyanacobalamin, and daily sublingual methyl B12 that I get pretty cheap at a health food store.


  31. 31 Julie

    I am currently doing very well on subcutaneous injections of methyl b12 3x week, while my children are on subq injections every 3 days. If you’re feeling lousy at the end of a month, why not go every two weeks if needed?

  32. 32 Donnie

    I’m 30 years old now and have been getting the cyanocobalamin injections since I was 4 years old. Back then, I was vomiting and having migraines, and nobody knew what was wrong with me until I was diagnosed as having a severe B-12 deficiency. As soon as they started me on the monthly injections (my bowel bisection from when I was a baby made it so I could not absorb vitamin B-12 from food or supplements), the vomiting and migraines stopped almost instantly. If my mom was even a little late on getting me in to the pediatrician to get my monthly shot, I would start getting headaches, but once I got my shot, I was fine again.

    As I got older, for some reason, I stopped getting the headaches and nausea if I went for awhile without the B-12 shots. As a result, when I was in high school and it was up to me to get myself to the doctor for my shot (nobody, at the time, ever informed me I could give it to myself), I would wait a little bit longer each time between shots. Then, during my senior year in high school, I pretty much stopped going to get the shots altogether at one point, and I did not have any observable adverse effects. For whatever reason, my doctor thought this meant that my body had somehow compensated and didn’t need the B-12 injections anymore. So I stopped getting them.

    Fast forward about 4 years. In college, though my studies started out well in the first year or two, I started struggling severely in my third and fourth years. I had always been a straight A and B student all throughout my educational career, but all of a sudden I was having trouble focusing on my studies, and I was dropping out of classes left and right because I was failing and didn’t see the point in continuing the classes if I wasn’t able to keep up and do the work. I would read and study without ever really retaining anything. It was a nightmare, and I didn’t know what was wrong with me. At first I thought that maybe the work had just gotten more difficult and that I wasn’t cut out for it. But I didn’t really believe that. One night, I had a total breakdown and, crying and freaking out, asked my mom if i had some kind of late-onset retardation. Though this might sound extreme and unreasonable, I was not in a good frame of mind and really thought there was something wrong with me. So I went to the doctor.

    Based on my signs of depression and listlessness along with my inability to focus on my schoolwork, the doctor ordered a blood test, and voila! Wouldn’t you know it? A vitamin B-12 deficiency. Afterward, I read stuff online that talked about how if a person with this deficiency goes for even a little while without B-12 they can start to develop “dementia identical to the early stages of Alzheimer’s disease.” Scary stuff.

    Long story short (ok…not so short…sorry), I started getting my vitamin B-12 injections again, and now I give them to myself. Consequently, I was able to easily finish college, and six years later, I am now doing fine.

    I am curious about the difference between cyanocobalamin and methylcobalamin, however. Until recently, I didn’t know about anything besides cyancocobalamin. I just went with what my doctor prescribed. I guess I’ll ask about methylcobalamin next time I have an appointment.

    I know that nobody asked for my life story, but I just wanted to show some of the people who have been commenting that sometimes vitamin B-12 injections are absolutely necessary.

  33. 33 Tony B.

    Hi Donnie…..cyanocobalamin has cyanide in it and is bad to use everyday and can cause organ damage. It also has to be processed through your liver before getting into your system to work.

    The methylcobalamin skips the metabolize step and goes straight into your body and nervous system……much better to use and does not have cyanide in it.
    I am on my 3rd bottle of cyanocobalamin since June and will be getting the hydroxocobalamin and a bottle of b complex which I heard is really kicking next. .
    I’ve had a bowel re section too……

    keep us informed….

    Tony B

  34. 34 brendan stallard


    I’d really love to know where you got the injectable Methylcobalamin from, I’ve been searching high and low and can’t find supplies of it.

    Please help.


  35. 35 gail

    Can anyone comment on weather or not methylcobalamin may help my DOG? She has a neuro problem that the neurologist thinks is an immune problem. She has poor balance and nystagmus starting last winter. Slow progression, but to the point now where she hesitates to do some things. Her serum cobalamin is within normal range but is on the low normal side. It is through my own research that I am going to try mythylcobalamin for her. My vet has traced a supplier to Hopewell NJ or Post Haste pharmacy. There are no suppliers that they us which have this item. I am starting her on cyanocobalamine tomorrow while we wait for her script from Hopewell. Thank you for comments.

  36. 36 Julie

    Interesting question… not really sure whether it would help your dog, but it certainly can’t hurt to try. I’d be willing to bet that it will. I just wanted to make a comment that the prices at Post Haste Pharmacy are MUCH cheaper than at Hopewell in New Jersey. We paid at Post Haste (who does not file insurance BTW) the same price as what we paid for our copay at Hopewell. In our home, the quality of product was the same. Considering it is unlikely you will have insurance coverage for your dog lol I would recommend going with Post Haste. Good Luck!

  37. 37 Xan

    A source for injectible methylcobalamin:

  38. 38 brendan stallard


    Nope, they only supply sublingual.



  39. 39 Julie

    Actually, with a RX from your Dr., Poste Haste pharmacy does supply methylcobalamin
    injections. It may not be listed on their website for purchase, but if your doc sends in the script, or calls it in, you can indeed get the injectables from them. I believe that I paid around $25-30 a month for a supply of 12 injections. We switched to a different pharmacy that took our insurance about two months ago. If you have a doc that will rx for you, call Poste Haste and ask to speak to their compounding pharmacy and check it out.

  40. 40 rhonlee

    My doctor recommended I try a fairly new prescription form of b12 and folic acid called Cerefolin NAC, instead of the injections. I have been diagnosed with fibromyalgia along with another autoimmune disorder. I have suffered from debilitating fatigue and muscle soreness for over 4 years. My doctor did some blood work and my b12 levels were low normal and my vitamin D levels were low. I’ve also had some memory problems. I started the Vit D(1000 mg) and Cerefolin NAC and within 1 week I felt much better. I’ve been on it for 3 months and I’m now able to exercise everyday and no longer need to take naps due to fatigue. It’s also cleared up some chronic mild depression I’ve had. I highly recommend getting your vitamin levels checked by your doctor during routine physicals and asking about these supplements. No other medications I’ve tried over the last 8 years have had such a positive effect on my physical and mental health.

  41. 41 Jan

    My GP has me on 1000mcg injections once wkly, and starting today, I began injecting myself at home. I noticed the minute I opened my supplies from the pharmacy, that the little vials were red and not the usual clear color I’d noticed my gps’ nurse having always used. I’m guess the pharmacy doesn’t use Methylcobalomin, and what I got is Cyanocobalamin. I normally get a ’sense of well being’ within 30 minutes after the shots the nurse always gave me. This time. NOTHING ! I’m a little worried now reading that the ‘cyano’ is best for neurological probs, which I have, than the ‘methyl’. I know now that I’m gonna have to do some back tracking and see what’s happened. I hate to think I may have to wait a week, tho. I live in California. Is the Methylcoalamin only processed at compounding pharmacies? Anyone with any answers?

  42. 42 gail

    I got the methyl for my dog at Post Haste in Florida. She has neuro problems, undiagnosed. The vet showed me how to give shots and I have given her one myself. She has had a cyano and two methyl shots in the last two weeks or so. I also found methy in our health food store in quick dissolve tabs. You pop them under your tounge and they dissolve instantly. Called “No Shot”. I gave her two while waiting for the pharmacy. I have been taking them myself daily and I feel so-o-o-oooo much calmer. The pharmacist in Fl told me I was overdosing the dog so I stopped giving them to her. The good news is that she is showing improvement and at least no advancement of her neuro problems. I don’t worry about her falling down the stairs anymore. I have no idea if this will be a fix or a cure for her, or a placebo for me. All I know is that I feel better and so does the dog :) Lola’s methyl is clear with a slight tinge of pink. Will last two weeks in the fridge. I am grateful to my vet for writing the script so I can at least try this for her.

  43. 43 brendan stallard


    Hmmmm, I’m really surprised they’ve authorised that much quantity. Over in the UK, they won’t give you more than 1000mcg per three months, nothing like the once a month here in Atlanta, GA. (I travel to Yoorp a lot).

    What I’ve found out so far is that you can get Methylcobalamin, but I’ve only found it from places that supply to prescription. You can get three months supply, (one injection a month) and it only lasts in the fridge for three months, that’s why they won’t supply more.

    You can get it from:

    Who are nice and easy to communicate with. They told me it was about $25 a month, so $75 plus about $10 UPS.

    Good luck, if anyone has any better information, I’d be glad to hear it. On or off this list.

  44. 44 Xan

    Jan, vitamin B12 is red.

    Gail, one cannot overdose on B12 as any excess is eliminated from the body. The liver and kidneys naturally store a small amount - a few milligrams - but beyond that there is no accumulation. This also means that taking too much is just wasteful.


  45. 45 Tony B

    True but be careful of the “cyan” because this contains cyanide and trace amounts of aluminum ….check on info for the other hydroxocobalamin B12.
    Google as much as possible….


  46. 46 Julie


    I am currently receiving, by prescription, from Hopewell Pharmacy in New Jersey a quantity of 12 mb12 injections per month, around 1200mcg each injection. I have had this script filled in the past at Coastal Compounding, Poste Haste in Florida, and we are now at Hopewell because they will file our insurance for us.

    My children are receiving ten injections each month (per thirty days), one of them at the same dosage I am at, the other who is only four years old at about a third of the dosage I am on. We pay only our insurance copay, and then one shipping fee to ship all of our rx’s together in one box. All three of us have tested very low in cysteine on blood tests. Cysteine is a precursor to glutathione which is the bodies master antioxidant and detoxifier. MB12 helps to raise cysteine levels which in turn contributes to the production of glutathione.

    Jan, all of our MB12 injections that we have received in the past, from the three pharmacies we have dealt with have been a very dark pink color. I did have a reaction to the injections from Poste Haste Pharmacy though, I was getting big welts at the injection site. Since we switched to Hopewell I haven’t had a problem. My kids and nobody else I know of has had this problem with Poste Haste or any other pharmacy for that matter…guess I’m just weird.

  47. 47 gail

    I am looking for a theraputic dose for my dog who has an undiagnosed neuro problem. She is taking .05 ml twice weekly. Her script is 10 mcg/ml. She weighs 38 lbs. Her problems began last winter and have been progressive. When talking to the compounding pharmacist, he told me that it may be quite a while before I may see her improve. Does anyone have any idea about how much she may need to have for optimal results? My vet is only going by what is in his book. But this was not his idea and he is totally unfamiliar with the treatment for her problem, which he is really not sure of either. Her symptoms are nystagmus and poor balance. She also has weakness in her rear legs which varies day to day. They do not think this is DM but it may be similar. She is still very active so I am hoping it isn’t too late to help her with this. I really want to get the doseage right though. If anyone knows of a website I could look at I would appreciate that info. I would think she could be dosed the same as a child of this weight??
    Thanks, Gail.

  48. 48 Julie

    Gail, I don’t know of any websites you could go to, but my 4 year old is about 38.5 lbs and his dosage is .05ml every three days at 25mg/ml. You can see my sons dosage is quite a bit larger than your dogs. Not sure if there is a huge difference in metabolism that would account for why a dog would need a smaller dose (maybe their metabolism is slower but I dont’ think so) but you could take this info to your vet and see what he says.

    Hope that helps.

  49. 49 Xan

    Gail, If it were me I would hunt for another vet with more experience with B12 for dogs.


  50. 50 gail

    Thanks Julie and Xan for your comments. Julie you child is certainly getting more than my dog. I think my best bet for this it to contact the neuro vet who saw her last summer. Perhaps they can figure it out.
    Thanks, Gail.

  51. 51 Tony B

    My friend says 1cc for every 150 lbs. at least for humans….

  52. 52 brendan stallard

    Tony B,

    1cc of “what”?

    Methylcobalamin, or Cyanocobalamin?


  53. 53 Tony B

    Hi Brendan I’m still on the Cyanocobalamin….. theres also a B complex with Cyanocobalamin and works a whole lot better which a friend is using and has a bottle for me this week….

    do you know if the meth is stronger than cyan cause of it going straight into your system?

    Tony B.

  54. 54 brendan stallard

    “I’m still on the Cyanocobalamin….. theres also a B complex with Cyanocobalamin and works a whole lot better which a friend is using and has a bottle for me this week….”


    Spill lad, wherefrom does thou obtain it:)

    “do you know if the meth is stronger than cyan cause of it going straight into your system?”

    I don’t know that I’d choose the word stronger, and I have to admit I haven’t tried it yet, I’m soon to, soon as I can get a script.

    That said, all I’ve heard so far is positive. It appears to have a better effect, crosses the blood brain barrier, and does without the cynanide in good ole normal B12. There’s a bunch of research papers around that seem to suggest it helps old timers disease.

    As soon as I get mine, I’ll report back, I’ll be getting it from coastal

    I wish Zan, after having tuned us all up, would reveal some sources.


  55. 55 Tony B

    Try this place…this bottle has 30 shots in it….
    alot of pet stores online sell it too…
    always make sure it doesn’t come from china…

  56. 56 brendan stallard


    Heh: I put a reference up to that fella earlier in the thread, its where I get mine own from:)

    I have got a bottle of this in the fridge:

    Its on back order right now, but all the muscle types use it and say its just fine, much cheaper too.

    I’ve just taken this photograph of the difference between the granville (human) bottle, and the calvet (animal) bottle, that picture is here.

    I travel a lot, regularly to Yoorp and it means going through security and customs in Gatwick and Theifrow….oh my word, customs nearly had a fit when they saw all the syringes, needles and (OH…NO) DRUGS…..

    Wos cycanobalickamoon, when its ‘at ‘ome then? An…all these needles, wotchew want wiv them, eh?

    Yada yada…..I only took ‘em through the once….


  57. 57 Xan

    Resources for methylcobalamin:

    These pharmacies make up compounds of injectible methylcobalamin but not by ordering online… only by a phone call.

    Hopewell Pharmacy 1-800-792-6670

    PosteHaste Pharmacy 1-954-989-6524

    Siblingual or “lozenge” methylcobalamin, with and without folic acid, is available in health food stores.


  58. 58 brendan stallard


    My last mail in response to Tony B was flagged as ‘Spam’, (oh the shame).

    It had three links in it, I expect that’s why.

    Would you check moderation and release it if you are happy to do so?



  59. 59 Xan

    Here’s another compounding pharmacy to add to the list of resources for injectible methylcobalamin:

    Coastal Compounding Pharmacy 912-354-5188 or 866-354-5188


  60. 60 Xan

    Sorry, brendan, I’m not a moderator, just a participant like you. :-)


  61. 61 Babak

    Brendan, your “spammy” comment has been rescued - see above. Keep it clean from now on, ok? ;)

  62. 62 Xan

    I ran across this article about nasal methylcobalamin, which seems to work for people who have trouble with the injections and sublinguals… (And maybe for young children and animals?)

    But I haven’t located a source for it. Probably the compounding pharmacies would make it up for you.


  63. 63 Julie


    Other compounding pharmacies that make injectable MB12 are Lee Silsby, Wellness and Park. I believe I have posted Lee Silsby before, in addition to Coastal Compounding, Poste Haste and Hopewell but you seem to only read (or believe) info from Xan….. You can get the numbers of Lee Silsby and Park by googling.

    I don’t know of any sources for nasal MB12 without a prescription, however New Beginnings Nutritional has a product called Methyl Mate that many parents of children with autism use in place of a script of MB12 spray when they can’t obtain one from their doc. It apparantly works very well. Here is a link and hopefully it will be allowed to post-

    There is also an OTC MB12 nasal spray being formulated now…. I believe they are close to completion but not quite there yet.

    Forgot to say that Coastal, Lee Silsby, Wellness and Park Pharmacies are confirmed sources for compounding MB12 nasal spray with a prescription.

  64. 64 Tony B

    Good info guys!!!
    Brendan yeah I had calvet down as a source but saw they were back ordered so I didn’t post it…
    use google search as much as possible ….but it looks like we have added about as many links as we can without repeating anymore……

    Thanks for the photo ;)
    that 250ml bottle is huge!!!! I heard to keep it in the fridge and don’t freeze it…

    I’ll report back after I finally get my hands on the b complex….

    Tony B.

  65. 65 brendan stallard

    “you seem to only read (or believe) ”


    Sorry I gave that impression, but not so.

    I have read every single message in this very popular thread, and there are a whole lot of messages from folks giving positive messages, but not a lot of detail. Its great to hear the positive messages, but googling does not always provide a simple path to nirvana.

    In every case where I’ve posted information, I’ve given a link to where I’ve got the product from.

    I was only asking for those folks who DO have the stuff, to be a bit more clear where they get it from, is all.

    Methylcobalamin, for all its apparent virtues, is not the easiest stuff on the planet to obtain, or at least obtain in the correct composition.


  66. 66 Xan

    More compounding pharmacy info:

    Lee Silsby Pharmacy - 1-800-918-8831

    Wellness Pharmacy - 1-800-227-2627

    Park Pharmacy - 1-866-551-7195

    The MethylMate Julie mentioned is a very absorbable liquid that is given orally, 5 drops per day, so it would be very easy for young children, animals, and others.

    That link again:


  67. 67 gail

    So, I spoke with my dog’s neuro and he said she should have 250-500 mcg per day. Her vet here told me .5 ml twice a week. Her script is 10 mcg per ml. So she is getting a fraction of what she should be getting. I wonder why I didn’t ask the neuro to begin with. He also said to give sublingual if I prefer. She will let me pop them under her tounge and seems to not really know they are there. But of course I won’t know how much she is really getting that way. The neuro also told me that it will not do anything more than make her feel better, which I think she does even on a small dose. Sorta kinda bummed about it. He told me usually within a year or two the dog will die :( It will be a year this winter that she started.

  68. 68 Tony B.

    Gail is your dog walking in circles? How long does it sleep? Mine goes to the left in circles but still has a moderate appetite….
    I think the small doses are because of their kidneys are sensitive to alot of things…

  69. 69 Xan


    How about trying MethylMate, which is an oral liquid. Great for animals and very young children.

    That link again


  70. 70 brendan stallard

    Tony B,

    I used my large bottle of B12, the one from Calvet for two weeks injections now and I can’t note any difference whatever between the two, apart from the human one being about 200 times the price.


  71. 71 Dan

    As far as amounts of methylcobalamin, i’ve been prescribed an injection solution containing 5 milligrams (5000 micrograms) per milliliter. Its made by an Australian company here in Perth


  72. 72 Boo Radley

    There is no known toxicity for methylcobalamin. Injected cyanocobalamin on the other hand can be dangerous in megadoses. I’m not sure why people go all weird when someone talks about injecting vitamins. I inject once a weak a b complex preparation.

    B12 deficiency is something that I’m positive is much more prevalent than doctors believe. Many breakthroughs in modern medicine have been made by laypeople who never even *looked* at a college. It is absolute arrogance to say that only ‘trained medical professionals’ are competent to make judgments about these things.

    I’m giving my Mom 1000mcg of methylcobalamin in injection form every other day. It’s possible that it is good to slow or halt age-related neurological degeneration. But I’ve found Methyl-Mate, which you can order online. Liquid sublingual, that can also be used as a nasal spray. You have to request that they send you a nasal spray bottle with it, but they will free of charge. I found out that you can absorb up to 50% of the methylcobalamin taking it as a nasal spray, as opposed to perhaps 10-15% from taking it sublingually. And with the sublingual, you probably have to keep it under your tongue longer than the label says in order to absorb 10-15%.

    Anyways, methyl-mate can be ordered online. It’s like 35 dollars a bottle (not including shipping), and most outlets will send you a complimentary nasal spray bottle with it if you ask them to. 5 drops is 1385 mcg of methylcobalamin. But If you spray, 1 spray is equal to 500 mcg. According to the label, there are 108 doses in the bottle of 1385 mcg. This is a product that is purchased by many parents of autistic children.

  73. 73 gail

    I am about to re-order the injectable for my dog. I have since talked to her neuro Dr. and according to him I should give her 200-500 mcg every day. I do not want to inject her every day and this amount is enormously more than what her regular vet has prescribed; 5 mcg twice a week. Since it is so vastly different her vet has agreed to prescribing her methyl at 200 mcg/ml and give one cc twice weekly. If I see a difference in her symptoms then maybe go higher. She weighs 37 lbs.

  74. 74 Tony B.

    Good post Boo. So does your mom respond well to the injections or the sublingual better?

    Where do you give your dog the shots? Hind quarter? In the muscle. I heard if you don’t get into the muscle then 50% of the shot is wasted and will be just expelled by the body. Or do you pull the skin up in a V and do it that way?

    I’m still using the B complex injections….some shots work good and I can feel it kick in and some don’t …very strange…

  75. 75 gail

    The vet said under the skin or in the muscle. I chose under the skin because I don’t like hurting my dog. Seems like if it is in the tissue it would be absorbed the same.

  76. 76 Tony B.

    Yeah I thought that too but it kinda gets filtered away….so thats probably why he wants you to give such a high dosage cause its not getting to the muscle….but the body will only use what it needs anyway…so don’t go any higher than what the vet says…..I think you are doing good don’t worry. :)

    I’ve read alot on body building sites about this issue….

  77. 77 bILL

    To rhonlee who posted on Oct 28th, 2008 at 9:08 am and any others that have fibromyalga or other autoimmune diseases. I recommend you look at Low Dose Naltrexone. At my compounding pharmacy here in california we are doing a fair amount with it, for various autoimmune diseases, with some very interesting successes. My wife has fibromyalga and it has given me my wife back, you know, the one with some energy, zest for life, not hurting all the time, can do things. By the way Grandpas Pharmacy in Placerville California and Prescription Specialists in Woodland California can both do the sterile injectable form.

  78. 78 Xan

    Those of us who give self-injections are advised to do it subcutaneous rather than intramuscular as it is less risky. As I understand it subQ is equally effective as IM, and could be even better as absorption is slower.

    But why give injections to an animal or a child when the nasal spray is available and effective?


  79. 79 Boo Radley

    With the nasal spray, you have to voluntarily snuff the stuff up into your nasal passages rather intensely, so that it doesn’t flow out, or run down into your throat too quickly. With that in mind, I’m sure you understand why it would be an issue with many kids, particularly small ones, and badly autistic ones. Animals, well I’ll not insult you by explaining that one, either.


    Another thing about the spray…you have to pick out red boogers. Seriously.

    I take the nasal spray as well, and I can tell you, it *is* a little bit uncomfortable directly after spraying. Kind of like getting a little water up the nose, but it goes away quickly. For some, the shots are less of a bother than the nasal spray, less uncomfortable. Also, while the nasal spray works for many people, it may be that some folks just can’t absorb much that way. The injections give more peace of mind, as they are the surest form of delivery, and less of the methylcobalamin is wasted. I shoot b complex (minus the b12), and snort the methyl-mate.

    I’ve heard a father tell how he injects his sleeping son, and it never wakes him. With the insulin needles, it is possible. But he’d have to have an awfully steady hand.

    I don’t know if subQ absorbtion is slower than IM. But I have been told that it is almost as good as IM. With frequent megadoses, I wouldn’t imagine it makes much difference. But that’s just me, and I haven’t studied that bit of it very much yet.